The interesting phenomenon is that last week, it was in Bridge that the pictures looked muted, and more saturated in Photoshop. I haven't recalibrated in between, but i have used the display calibration little app you advised, to restore the calibration.
Ive been working on calibrated screens for 10 years now and this is the first time I'm having issues. Is it possible that it's an issue with my new computer? Possibly the graphics card?