Okay @Damien Symonds kids are to bed. Ran the Glary Utilities and cleared up quite a few errors. Checked scratch disks for Photoshop and Bridge cache folder. Both are on the C driver. Apparently I have an empty solid state drive so I'll get those things moved.
I took a screenshot, but saw something interesting in ACR and it was the first time I caught it. About 10 seconds after the Raw file opens in ACR, the histogram changes and the picture darkens but none of the settings change. When I close it and go back out, the image in Bridge looks like the original image that opened before it darkens. I opened a couple of the different affected files and they all did this. 5-10 seconds after opening, histogram shifts towards the black end and image darkens.
Can you see the difference in these two? When you click back and forth it's obvious but I'm not sure how much you can see here. Her skin is darker, the greens are darker, and the sky is slightly grayish in the jpg.